Menu

Goldfish Health Disease Symptoms and Cures

Goldfish World Hobby Site

What To Do About Sick Koi and Pond Fish in 2018

An orientation to sick Koi and pond fish crises for 2018. An overview of what you can do to start reigning in fish losses. 

Help For Sick Fish Koi & Pond Fish Disease Season 2018 Intro
"My Fish Is Sick, What Should I Do?" is the cry of the season, and it's all going back to water quality. I got off the phone with a person who assured me the situation with his pond was bacterial and not water quality. I said "To help you ANY more, I will require n actual number for the pH Ammonia and Nitrite. And an actual number for temperature, not "They're all good" 
He emailed back:   "My pH has crashed. You were right. It's 6.2"  And so the bacterial lesions he was seeing were actually the least of his worries and probably caused by the deteriorated water. So there's that. 

 

Apoquel and Cancer in Dogs

Dogs are contracting cancer from a new medicine (introduced in 2013) given to control itching. 
#apoquel #canine #dog #cancer #oclacitinib

In the most basic of "summaries": You can't use it in people, and it causes new cancer in about 15-18/300 NON-elderly dogs. Severe bacterial/fungal infections in @30-35/300 dogs.

Now let's get to the meat and potatoes:

Video "Apoquel and Cancer in Dogs"

A customer asked me about a new medication called Apoquel. It is prescribed for dogs that are itching because of allergic reactions to substances, fleas, and more. Apparently it is effective in many of the cases it is used in. If you check the internet, you will read hysterical reports from some of the dog breeder sites that say that "50% of animals getting Apoquel will die of cancer". Not surprising. However a veterinary dermatologist who prescribes Apoquel regularly arrives at a more refined / conservative conclusion per the packaging material and that is that about 5% of animals getting apoquel will suffer cancer. However in that author's opinion (the dermatologist's) it was thought that 5% of non-elderly animals would have gotten cancer over the course of a year anyway. I disagree. Because, if you read the testing results more closely they were able to attribute specific cancers to Apoquel. It was not usually random; in the types of cancer contracted. Later on in this article I will list the specific answers researchers found in Apoquel studies.

In almost all of the trials, cancer was not the most common negative side effect. Severe infections and pneumonia were also noted to the extent that in some cases the trial had to be stopped for those animals. Depending upon how you interpret the results of these studies, upwards of 10 percent and possibly closer to 20 percent of animals had significant reactions that compromised quality of life as a result of this medication.

Apoquel has been around a while. It was out in late 2013 and was not tested in many animals at all. It has a fearsome list of direct effects…..and to create THAT much cancer and pneumonia in such a tiny study group of no more than 500 dogs, total. :u(

Better than twelve percent of all dogs given Apoquel developed: pneumonia, bullous foot and node infections, or any one of a dozen cancers directly related to Apoquel.

It isn't used in people, and even has hazard instructions if you simply get it on your skin. (Open / broken capsule)

300+/- Dogs in field trial: 
Eighteen dogs were euthanized because of suspected malignant neoplasms: including thoracic metastatic, abdominal metastatic, splenic, frontal sinus, and intracranial neoplasms, and transitional cell carcinoma after 17, 120, 175, 49, 141, and 286 days of APOQUEL administration, respectively. Two dogs each developed a Grade II mast cell tumor after 52 and 91 days of APOQUEL administration, respectively. One dog developed low grade B-cell lymphoma after 392 days of APOQUEL administration. Two dogs each developed an apocrine gland adenocarcinoma (one dermal, one anal sac) after approximately 210 and 320 days of APOQUEL administration, respectively. One dog developed a low grade oral spindle cell sarcoma after 320 days of APOQUEL administration.

From the above statistic, what is commonly overlooked is that those all occurred within a group of less than 300 animals.

When they went from clinical to field trials; 6% (six-point-zero-percent) of their study got cancer!

Infections were essentially twice as common (@10%) but only a few were life-threatening or lethal.

Nutshell?
It's just too immunosuppressive.

The doctor-to-consumer selling point is; "It won't cause thirst hunger and weight gain like prednisone-category meds". Which is crazy-attractive I know. But the risks are too high in most patients with the garden variety itching.

This may come as a big surprise to some people, but drug manufacturers quite possibly rely on the fact that folks won't read the fine print, and I suspect even some doctors won't. When I refer to fine print I am NOT necessarily talking about the 'massaged' fine print provided by the manufacturer. Sometimes better and more accurate information can be interpreted from National Institutes of Health, publicly funded research and university level tracts, and PubMed.

Apoquel is powerfully immune suppressive, not unlike Cyclosporine (Atopica°) however Apoquel is in a drug class and category by itself.

So far, I don't know much that is as safe, or cheap as steroids for skin issues (whose cause is exclusive to other infectious causes), but; nutrition is making headway.

Erik

Dr Erik Johnson
3100 Roswell Rd Suite 113
Marietta GA 
TEL: (770) 977-5377
FAX: (770) 973-0301

Dec 2017: I have posted a video of the first dog I've gotten off Apoquel (without cancer). We took advantage of information on low carb / carb intolerance in dogs. His video is somewhere in this thread. Sorry. 
I put details and citations of this article at: drjohnson.com/apoquel.html
"Sciency" folks wanted me to 'back up my random internet post' so I just linked to Zoetis' own prescriber information. That was easy peasy. I'm sure they wish they didn't have to post their fine print on the internet LOL.

For the record, I don't like Prednisone much either. It's the mildest thing (that works) for now, but I am ALWAYS on the hunt for the Grail.

Addendum: Between the above writing and July 2017, I have put five cases on it after a lot of discussion with owners about possible consequences. I am already back down to four cases on Apoquel since Bella T. now has lymphoma and has left the group. In fairness, Bella was better off dead than in the skin she lived in before Apoquel. Which is the only criteria I use these days before putting a dog on Apoquel. It works extremely well.

For more pet related videos please visit dr Johnson's Youtube Channel

Dr Johnson's Facebook Page

 

Apoquel and Cancer in Dogs

Dogs are contracting cancer from a new medicine (introduced in 2013) given to control itching. 
#apoquel #canine #dog #cancer #oclacitinib

In the most basic of "summaries": You can't use it in people, and it causes new cancer in about 15-18/300 NON-elderly dogs. Severe bacterial/fungal infections in @30-35/300 dogs.

Now let's get to the meat and potatoes:

Video "Apoquel and Cancer in Dogs"

A customer asked me about a new medication called Apoquel. It is prescribed for dogs that are itching because of allergic reactions to substances, fleas, and more. Apparently it is effective in many of the cases it is used in. If you check the internet, you will read hysterical reports from some of the dog breeder sites that say that "50% of animals getting Apoquel will die of cancer". Not surprising. However a veterinary dermatologist who prescribes Apoquel regularly arrives at a more refined / conservative conclusion per the packaging material and that is that about 5% of animals getting apoquel will suffer cancer. However in that author's opinion (the dermatologist's) it was thought that 5% of non-elderly animals would have gotten cancer over the course of a year anyway. I disagree. Because, if you read the testing results more closely they were able to attribute specific cancers to Apoquel. It was not usually random; in the types of cancer contracted. Later on in this article I will list the specific answers researchers found in Apoquel studies.

In almost all of the trials, cancer was not the most common negative side effect. Severe infections and pneumonia were also noted to the extent that in some cases the trial had to be stopped for those animals. Depending upon how you interpret the results of these studies, upwards of 10 percent and possibly closer to 20 percent of animals had significant reactions that compromised quality of life as a result of this medication.

Apoquel has been around a while. It was out in late 2013 and was not tested in many animals at all. It has a fearsome list of direct effects…..and to create THAT much cancer and pneumonia in such a tiny study group of no more than 500 dogs, total. :u(

Better than twelve percent of all dogs given Apoquel developed: pneumonia, bullous foot and node infections, or any one of a dozen cancers directly related to Apoquel.

It isn't used in people, and even has hazard instructions if you simply get it on your skin. (Open / broken capsule)

300+/- Dogs in field trial: 
Eighteen dogs were euthanized because of suspected malignant neoplasms: including thoracic metastatic, abdominal metastatic, splenic, frontal sinus, and intracranial neoplasms, and transitional cell carcinoma after 17, 120, 175, 49, 141, and 286 days of APOQUEL administration, respectively. Two dogs each developed a Grade II mast cell tumor after 52 and 91 days of APOQUEL administration, respectively. One dog developed low grade B-cell lymphoma after 392 days of APOQUEL administration. Two dogs each developed an apocrine gland adenocarcinoma (one dermal, one anal sac) after approximately 210 and 320 days of APOQUEL administration, respectively. One dog developed a low grade oral spindle cell sarcoma after 320 days of APOQUEL administration.

From the above statistic, what is commonly overlooked is that those all occurred within a group of less than 300 animals.

When they went from clinical to field trials; 6% (six-point-zero-percent) of their study got cancer!

Infections were essentially twice as common (@10%) but only a few were life-threatening or lethal.

Nutshell?
It's just too immunosuppressive.

The doctor-to-consumer selling point is; "It won't cause thirst hunger and weight gain like prednisone-category meds". Which is crazy-attractive I know. But the risks are too high in most patients with the garden variety itching.

This may come as a big surprise to some people, but drug manufacturers quite possibly rely on the fact that folks won't read the fine print, and I suspect even some doctors won't. When I refer to fine print I am NOT necessarily talking about the 'massaged' fine print provided by the manufacturer. Sometimes better and more accurate information can be interpreted from National Institutes of Health, publicly funded research and university level tracts, and PubMed.

Apoquel is powerfully immune suppressive, not unlike Cyclosporine (Atopica°) however Apoquel is in a drug class and category by itself.

So far, I don't know much that is as safe, or cheap as steroids for skin issues (whose cause is exclusive to other infectious causes), but; nutrition is making headway.

Erik

Dr Erik Johnson
3100 Roswell Rd Suite 113
Marietta GA 
TEL: (770) 977-5377
FAX: (770) 973-0301

Dec 2017: I have posted a video of the first dog I've gotten off Apoquel (without cancer). We took advantage of information on low carb / carb intolerance in dogs. His video is somewhere in this thread. Sorry. 
I put details and citations of this article at: drjohnson.com/apoquel.html
"Sciency" folks wanted me to 'back up my random internet post' so I just linked to Zoetis' own prescriber information. That was easy peasy. I'm sure they wish they didn't have to post their fine print on the internet LOL.

For the record, I don't like Prednisone much either. It's the mildest thing (that works) for now, but I am ALWAYS on the hunt for the Grail.

Addendum: Between the above writing and July 2017, I have put five cases on it after a lot of discussion with owners about possible consequences. I am already back down to four cases on Apoquel since Bella T. now has lymphoma and has left the group. In fairness, Bella was better off dead than in the skin she lived in before Apoquel. Which is the only criteria I use these days before putting a dog on Apoquel. It works extremely well.

For more pet related videos please visit dr Johnson's Youtube Channel

Dr Johnson's Facebook Page

 

Finding Cool Dog Beds and Carpeted Pet Stairs.

So there comes a time when you need to find a set of stairs or a ramp to help your dog get up onto the bed? I mean, if your dog sleeps on the bed. 

So what I've done is curated a mess of dog beds and steps that are functional, well rated, and attractive. My personal favorite are the higher quality, furniture grade dog steps / stairs with carpet on the runners. It's amazing how many different sizes and prices are available. 

So when I built http://hscri.org/ I made the site to allow you to sort JUST dog beds and stairs and then sort them by price. I specifically omitted crappy dog beds. The kinds of dog beds that a dog wouldn't use unless they HAD to. Like if they were caged with the dog bed, they'd use it. 

And of course in the Cool Dog Beds section I put dog beds I'd like to have for ajax. 

So check out the dog steps and stairs at HRSCI.org

Thanks

Dr Erik Johnson

 

How To Tell If Your Koi Food Is Good Or Bad?

How Can You Tell If Your Koi Food is Good Or Bad?

Do You Know How To Read and Assess A Koi Food Label?

Is Your Koi Food Priced On Par With Better Foods?

src=http://2uv.com/wp-content/uploads/2018/03/Koifoods_intro_square_image_mockup-e1520538394984.jpgKoifoods.com is a curated web site where Dr Erik Johnson rates and assesses more than twenty Koi Foods and teaches about Koi nutrition, nutrients, and feed labels so you can understand what's going on, and make good choices. 

Then, the Koi foods are broken into groups (ratings) and you can even shop by quality and price. 

Some very good foods can be bought very affordably. 

Some of the very most expensive foods (over $10/lb) are poorly formulated. But you'd never know without Koifoods.com

Learn about Koi and Pond Fish Nutrition, read the articles and shop the shop. You can choose from A, B and C grade foods and for a real savings, buy food from the "I Wouldn't Feed This to MY Koi" category lol

Now, a word on that…If the food is in the "I Wouldn't Feed…" category it usually means there's a cheaper food with better formulation. NOT that the food is badly done. 

Dr Erik Johnson

 

Axolotl Content

Visit Brutle.com for a lot of interesting stuff. Just today I'm uploading a LOT of Axolotl content in a hugely Video format. All the clicking has been done for you and the videos are the best of the best. 

I hope you like it. 

http://www.brutle.com

Axolotl: Not a Little But a Lottle

Axolotls are a mix between a Pokemon, the Dragon from "How To Train a Dragon" and well, that. Cute and adorable. Interesting and now, coming out in more and more great colors and sizes. 

Axolotls are the "neotinic" form of Salamanders. The form BEFORE they drop their gills and become salamanders. They’re laid as eggs in a mucinous egg mass not unlike a mess of frog eggs. There may be hundreds and even thousands. 

They hatch out and immediately start eating freshly hatched Brine Shrimp and other tiny live food. A good breeder can keep the water clean and preserve a LARGE percentage of the brood. 

The parents don’t take any care of the babies. I’ll post another article soon about how the Axolotls actually "breed" which, too, is pretty impersonal. 

Have you seen the Axolotls of Georgia Facebook Page? 

You might also like my Youtube Channel linked below. 

I’m just starting to keep Axolotls as pets and I will share my experiences on these as I go. Right now I just love the way they move around, and how smart they seem to be. At feeding time they brighten up and approach the front of their enclosure and their babies are simply adorable. 

Dr Erik Johnson

Renal Disease in Dogs: TUMS?

Kidney Failure in Dogs

How to Improve the Survival of Dogs With Kidney Failure

Hyperphosphataemia in patients with chronic kidney disease, particularly those on dialysis, can be ameliorated by oral phosphate binders in conjunction with dietary phosphate restriction.

Although phosphate binders reduce serum phosphate in these patients, it remains uncertain whether they improve clinical outcomes.

Calcium-based binders are frequently used, but their popularity is waning due to emerging evidence of accelerated vascular calcification.

The use of aluminium-based binders has been limited by a perceived risk of aluminium accumulation.

The non-calcium-based phosphate binders – sevelamer hydrochloride, lanthanum carbonate and sucroferric oxyhydroxide – have become available and subsidised by the Pharmaceutical Benefits Scheme for patients on dialysis.

The pill burden and adverse effects (particularly gastrointestinal intolerance) associated with the expensive, non-calcium – non-aluminum phosphate binders (sevelamer ) often contribute to poor medication adherence.

Calcium carbonate is the most common form of phosphate binder prescribed, particularly in non-dialysis chronic kidney disease. It is typically given to patients with advanced chronic kidney disease, including those receiving dialysis. As with all phosphate binders, calcium-based binders are most effective when taken with meals (which also limits calcium absorption).10 They should be prescribed in conjunction with moderate dietary phosphate restriction, ideally supervised by an accredited practising dietitian. Phosphate-rich foods with a high phosphate to protein ratio (processed foods, fast foods and cola drinks) are best avoided, while foods with a high biologic value (e.g. meats and eggs) should be retained to maintain nutritional status.11,12

Calcium-containing phosphate binders
Calcium binders have historically been an appealing first choice, because they also address the hypocalcaemia that is often seen with hyperphosphataemia in patients with chronic kidney disease. However, hypercalcaemia and accelerated vascular calcification are the main concerns with calcium-containing phosphate binders, particularly when they are combined with vitamin D therapy.5,15-18 The Kidney Disease Outcomes Quality Initiative Guidelines suggest that doses should not exceed 1500 mg/day of elemental calcium,19 based on evidence that this produces a positive calcium balance (excess body stores of calcium leading to soft-tissue and vessel calcification) in chronic kidney disease.20 However, there is little evidence of patient outcomes to support this recommendation. Another common adverse effect of these drugs is gastrointestinal upset, particularly constipation. The other main advantage of calcium-based binders is that they are inexpensive.

Calcium-based binders were associated with significantly lower serum phosphate (mean difference 0.07 mmol/L) when compared with sevelamer. However, sevelamer was associated with a lower risk of hypercalcaemia (risk ratio 0.45, 95% CI* 0.35–0.59) and a higher risk of adverse gastrointestinal events (risk ratio 1.58, 95% CI 1.11–1.25). There was no difference in all-cause mortality between calcium-based binders and sevelamer.51

Phosphate binders therefore effectively reduce serum phosphate in patients with chronic kidney disease, but it is uncertain whether they improve clinical outcomes. There may be a mortality difference between calcium-based and non-calcium-based binders, but it is not clear if this reflects a harmful effect of calcium-based binders, a beneficial effect of non-calcium-based binders or both.

BIBLIOGRAPHY:

Excerpts from:     https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313253/

What to Do About Cats Peeing Outside the Box

Cat Box Problems

Inappropriate Elimination in Cats

My Cat Pees Outside the Litter Pan

Cats that pee outside the litter pan may have a simple "issue" that is fixed by a very simple solution. A bigger litter pan. Did you know there was a study that revealed a 75+% successful method to get a cat to pee in its litter box again? Yeah it works. 

At Drjohnson.com there's an article that explains it all. There are FIVE Main Points to master and it's likely you'll fix the cat pee problem you're facing. 

Here's the link to Solving Cat Pee Problems in Two Easy Ways

Thanks

Doc Johnson

Disinfect Dog Mouths: Fight Infections

How to Improve or Fix Bad Breath In Dogs or 

How to Prevent Vegetative Endocardiosis (Bacterial Heart Valve Flap Disease) In Dogs

Infections Spreading from Mouth to Lungs and Heart in Dogs. 

Wow! I just found out Oxyfresh is available on Amazon! 

For oral infections: http://amzn.to/2E9iwCl

I've been recommending it to clients for literally YEARS except I've hesitated because it used to be a pyramid scheme behind the product. 
So how does it work and why?   

Well crust / tartar on the teeth comes from calcification (calcium hydroxyapetite) of the colonies of slime bacteria on the teeth. 
If you have slime bacteria, sooner than later you have plaque / tartar / crust. 
Well that's fine in dogs; because you can keep them in front of hard dental exercise which increases saliva, helps remove slime bacteria and can even mechanically chip away at tartar. 
In cats, not the same. 
Well anyway, enter Oxyfresh. It's basically good-tasting Listerine you can swallow. Great for pets for that very reason. They can drink it in their water, and it kills all their slime bacteria, hence, NO TARTAR, ever. 
Breath also improves A LOT. 
I recommend Oxyfresh for my older dogs to keep infections minimal. Especially older dogs who could be metabolically destabilized by a dental under anesthesia. 
But even for younger dogs, if you can eliminate the slime bacteria you do TWO things, first you improve breath and secondly, you short-circuit the formation of tartar. 

You can't drink Listerine! But with Oxyfresh they figured out a molecule with disinfectant properties that is instantly NEUTRALIZED by Hydrochloric acid in the stomach. 
So no gastrointestinal flora upset.

There is no substitute. Every year the drug reps come to the clinic with products that as "as good as Oxyfresh" and I've tried most of them, and they do not have the same molecule nor the same effect. Not even close. 

(We had a dog named Trudy that had fish breath and that's what worked. Exclusively. Even though we tried everything else available at the time)

Anyway, so now Oxyfresh is available easily at Amazon. Here's a link that makes me 0.12 cents a bottle lol

For oral infections: http://amzn.to/2E9iwCl